The organic anion transporter oat family

Author: kpex

August undefined, 2024

WebbSeveral families of multispecific organic anion and cation transporters, including OAT family transporters, have recently been identified by molecular cloning. The OAT family … WebbMentioning: 17 - The aim of this study was to explore whether rhein could enhance the effects of pemetrexed (PTX) on the therapy of non-small-cell lung cancer (NSCLC) and …

Drug and toxicant handling by the OAT organic anion transporters in th…

The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells o… Webb1 jan. 2015 · The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of attention … is melatonin derived from plants

The organic anion transporter family: from physiology to

WebbOrganic anion transporters (OATs) are shown in red, the organic cation/carnitine transporter (OCTN/CT) family is shown in blue, and organic cation transporters (OCTs) … WebbMentioning: 17 - The aim of this study was to explore whether rhein could enhance the effects of pemetrexed (PTX) on the therapy of non-small-cell lung cancer (NSCLC) and to clarify the associated molecular mechanism. Our study shows that rhein in combination with PTX could obviously increase the systemic exposure of PTX in rats, which would be … WebbBxPC-3 and MIA PaCa-2 pancreatic cancer cell lines were used to quantify transcripts of OATP 1B1 and 1B3. Results: OATP 1A2, 1B1, and 1B3 proteins were found ubiquitously … kidney disease and statins

Organic Anion Transporter Family: Current Knowledge

Organic anion transporters and PI3K–AKT–mTOR pathway …

Webb10 maj 2024 · Organic anion transport. This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the … Webb214 rader · Organic anion transporting polypeptides (OATPs in humans, Oatps in rodents) are multispecific transporters located in numerous epithelia throughout the body. They … is melatonin effective for sleepWebb1 juni 2000 · Organic anion transporter (OAT) is an heterogenous family of negatively charged proteins, mainly located in kidneys and the liver, but OAT1/OAT3 are also found … kidney disease and spinach

"WebbThe organic anion transporters ( OAT s), part of the SLC22 superfamily of transporters, are expressed throughout the body. However, the most clinically relevant members of this … " - The organic anion transporter oat family

The organic anion transporter oat family

The organic anion transporter family: from physiology to …

Webb1 jan. 2006 · Organic anion transporter (OAT) family Gene name Protein name Tissue distribution Predominant substrates SLC22A6 OAT1 kidney PAH, PGE2, urate, NSAIDs, … WebbWe explored an atenolol transporter from among the cation or anion transporters. • OCT1 expressed on apical side in enterocytes has transport activity of atenolol. • Transport of …

Did you know?

WebbThe organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of attention … WebbOATs are multispecific organic anion transporters, the substrates of which include both endogenous (e.g. cyclic nucleotides, prostaglandins, urate, dicarboxylates) and …

WebbOrgano-Anion-Transporter (Abk.OATP von englisch Organic Anion Transporting Polypeptide) sind Proteine in der Plasmamembran von Zellen unter anderem der Leber, …

WebbOrganic anion transporters play important roles in the elimination of a variety of endogenous substances, xenobiotics and their metabolites from the body. During the … WebbThe organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of attention …

Webb10 juli 2024 · Since, in the Oat3KO, the basolateral transport of organic anions by PT cells is dependent upon the remaining OAT (i.e., OAT1), treatment with probenecid should …

Webb1 aug. 2001 · Abstract The organic anion transporter (OAT) family handles a wide variety of clinically important compounds (antibiotics, nonsteriodal anti-inflammatory drugs, … is melatonin effective for insomniaWebb1 jan. 2015 · Abstract The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal … kidney disease and stomach problemsWebb39 rader · 1 jan. 2015 · The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 ... is melatonin fda approved for childrenWebbOrganic anion transporters (OATs) and organic cation transporters (OCTs) are members of the superfamily of transporters, Slc (solute carriers). Most are in the families Slc21 … is melatonin for insomniaWebbic anion transporter families, e.g. the organic anion trans-porting polypeptide (oatp) family or the Mrp (multidrug resistance-associated protein) family. On the other hand, the … is melatonin effective redditWebbGene Family The human SCL22 family of transporters encompasses at least 22 members with an additional six structurally related but not yet assigned genes. ... In Vitro and In … kidney disease and sore musclesWebb1 aug. 2001 · The organic anion transporter (OAT) family handles a wide variety of clinically important compounds (antibiotics, nonsteriodal anti-inflammatory drugs, etc.) … kidney disease and sore feet