WebMar 14, 2012 · Analysis of the STAT5B gene revealed a novel homozygous missense mutation, p.Phe646Ser, located within the βD′ strand of the SH2 domain. Reconstitution studies demonstrated expression of the p.Phe646Ser variant was less robust than wild type but, in contrast to the previously described STAT5B p.Ala630Pro SH2 mutation, could be … WebApr 10, 2024 · UMAPs on left indicate location of relevant cell types. (B and C) Genome browser tracks showing CDX2 ChIP-seq reads in SC-islets ... interleukins (STAT1–4, STAT5A, STAT5B, and STAT6), steroid hormones (AR, PGR, ESR1, and ESR2), thyroid ... Gene activity scores from snATAC-seq data and gene expression from sc/snRNA-seq data were then …
STAT5B - My Cancer Genome
WebFeb 14, 2024 · Homologs of the STAT5B gene: The STAT5B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and … WebMay 25, 2000 · Among STAT family proteins, Stat5a and Stat5b are the two most closely related STAT proteins. burgundy access bloemfontein
STAT5B (signal transducer and activator of transcription 5B)
WebNov 1, 2006 · STAT5 proteins are components of the common growth hormone and interleukin 2 family of cytokines' signaling pathway. Mutations in the STAT5b gene, described in 2 patients, lead to growth hormone insensitivity that … WebAug 1, 2011 · STAT5b is localized in the cytoplasm and translocates to the nucleus upon phosphorylation of Y699. However, unphosphorylated STAT5b has also been reported to … WebApr 10, 2024 · The alpha-thalassemia mental retardation X-linked (ATRX) syndrome protein is a chromatin remodeling protein that primarily promotes the deposit of H3.3 histone variants in the telomere area. ATRX mutations not only cause ATRX syndrome but also influence development and promote cancer. The primary molecular characteristics of … hall rental shoreline wa