WebIRF8 dampened signaling via the B cell antigen receptor (BCR), facilitated antigen-specific interaction with helper T cells, and promoted antibody affinity maturation while antagonizing IRF4-driven differentiation of plasmablasts. WebMar 10, 2011 · Western blot (bottom) shows the IRF8 protein level in total cell lysates. IFN-β transcription in monocytes stimulated with LPS for 2 hours, determined by real-time PCR (top). (B) The mapping of IRF8-binding sites across IFN-β genomic DNA using 5 different pairs of primers (bottom). Primary monocytes were stimulated with LPS for 1 hour before ...
3394 - Gene ResultIRF8 interferon regulatory factor 8 [ (human)]
Web(B) Relative reporter luciferase activity for Naip2 or Naip5 promoters in IRF8-overexpressing cells, presented as fold change with respect to empty vector (EV)-transfected cells. Data were normalized for transfection efficiency by normalizing firefly luciferase activity with renilla luciferase activity. WebApr 11, 2024 · CD8 + T cells are crucial for the clearance of viral infections. During the acute phase, proinflammatory conditions increase the amount of circulating phosphatidylserine + (PS) extracellular vesicles (EVs). These EVs interact especially with CD8 + T cells; however, it remains unclear whether they can actively modulate CD8 + T cell responses. In this … the original skin care reviews
Transcription factors IRF8 and PU.1 are required for follicular B cell …
WebAs such, IRF8 may be capable of repressing Ifit1 gene induction in cells such as pDCs and B cells, where it is present at high endogenous levels. Here we report that IRF8 regulates … WebJan 22, 2024 · Although IRF8 normally suppresses B cell differentiation to plasma cells , a process that positively contributes to EBV reactivation , the results of our current work and the studies of others support a model in which IRF8 facilitates the reactivation of EBV upon lytic induction . IRF8 plays a key role in maintaining caspase-1 expression, a ... WebJun 20, 2024 · IRF8 and EBF1 define pDC and B cell lineage dichotomy. To dissect the heterogeneity of the SP compartment, we used IRF8-eGFP and EBF1-hCD2 reporter mice, which express a 3′ IRES-GFP and an IRES ... the original six flags