Cisplatin kidney toxicity

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August undefined, 2024

WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer … WebNov 26, 2024 · In this way, HO-1 expression has been effectively described as a modulator of cisplatin-induced renal toxicity and its increase as a potential approach for decreasing kidney injury [49,50]. As described in these works, rectal O 3 /O 2 insufflation at appropriated concentrations enhances the antioxidant mechanisms in renal tissue, which …

Biomolecules Free Full-Text Cisplatin-Induced Kidney Toxicity ...

WebFeb 16, 2016 · However, a high-dose cisplatin regimen is associated with major toxic side effects (myelosuppression, neurotoxicity, ototoxicity, and nephrotoxicity). In cisplatin-based CCRT schedules, acute nephrotoxicity is commonly graded by an increase of serum creatinine levels, according to the Common Terminology Criteria for Adverse Events … WebCisplatin for injection can cause dose-related nephrotoxicity, including acute renal failure that becomes more prolonged and severe with repeated courses of the drug. Renal … rawlings scholarship

Cisplatin dosing, indications, interactions, adverse effects ... - Medscape

WebJun 18, 2024 · Typical adverse reactions associated with cisplatin include kidney damage, high emetogenic potential, peripheral neuropathy, ototoxicity, and hematological toxicity … WebFeb 1, 1989 · Cisplatin is a major antineoplastic drug for the treatment of solid tumors, but it has dose-dependent renal toxicity. We reviewed clinical and experimental literature on cisplatin... WebCisplatin is a potent tubular toxin with a high incidence of nephrotoxicity. Carboplatin is considered less nephrotoxic but can still cause tubular injury and interstitial nephritis in patients who have been previously treated with cisplatin. simple green mold remover

Cisplatin nephrotoxicity: a review of the literature - PubMed

The Nephroprotective Effect of Mannitol in Head and Neck Cancer ...

WebIntroduction. Cisplatin (cis-diamminedichloroplatinum(II)) is one of the most widely used first-line chemotherapeutic agents for a broad range of cancers.Cisplatin continues to be in widespread clinical use for various solid tumors such as ovarian, testicular, bladder, head and neck, and non-small cell lung cancers 1,2 but its usefulness is limited due to its high … WebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. simple green motorcycleWebJan 7, 2024 · Cisplatin has a well-documented array of toxic side-effects, of which some are potentially irreversible, including nephrotoxicity. 1,2 Accordingly, cisplatin infusion is usually combined with saline to hydrate and mannitol infusion to promote osmotic diuresis to prevent permanent damage to the renal tubules. 2–4 simple green mold and mildew cleaner

"WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … " - Cisplatin kidney toxicity

Cisplatin kidney toxicity

Pathophysiologic Mechanisms of Selected Types of Nephrotoxicity - Medscape

WebApr 12, 2024 · Evaluation of the effect of glycine infusions on the early renal uptake of cisplatin. Kidney platinum content was markedly lower in rats who had received glycine infusion compared to control rats who had received saline-infusion. ... Klastersky, J. Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin … WebWARNING: Cisplatin may cause severe kidney problems, nerve problems, and severe nausea and vomiting. Nerve problems may occur during treatment or weeks after …

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WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … WebHowever, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major mechanisms of cisplatin-induced renal toxicity involve oxidative stress, inflammation, and renal fibrosis, which are covered in …

WebSep 1, 2024 · Rucaparib was the most potent radiosensitiser and VE-821 was the most potent chemosensitiser. VE-821, PF-47736 and MK-1775 attenuated cisplatin-induced S-phase arrest but tended to increase G2 phase accumulation. In mice, cisplatin-induced acute kidney injury was associated with oxidative stress and PARP activation and was … WebCisplatin dose adjustment in patients with renal impairment must be improved. Estimating GFR with the aMDRD formula and adding an intermediary level of dose reduction for patients with eGFR from 50 to 59.9 mL/min may result in a higher cumulative dose of cisplatin without higher renal toxicity, whic …

WebMar 2, 2024 · Cisplatin is a potent anticancer drug widely used for the treatment of several malignant tumors. One of the most relevant side effects of cisplatin is nephrotoxicity, that is very well-known since its introduction in 1978 and limits its use and efficacy [ 1, 2 ]. WebAug 1, 2024 · Cisplatin can also cause direct nephrotoxicity as it accumulates within the renal epithelial cells leading to DNA damage and release of damage associated molecular patterns (DAMPs). As a consequence, cytokines and inflammatory cells are …

WebBoth in animals and humans, a variety of agents appear to alter renal uptale of cisplatin and its hemodynamic consequences, thus modulating nephrotoxicity. Thiosulfates and …

WebMar 22, 2024 · They exert their main toxic effect within the tubular cell by altering phospholipid metabolism. In addition to their direct effect on cells, aminoglycosides cause renal vasoconstriction. The 2... rawlings school of divinity sample paperWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … rawlings school of divinity facultyWebMay 18, 2024 · The high incidence of cisplatin-induced nephrotoxicity in elderly patients may be associated with renal hypoperfusion; increased comorbidities, such as chronic … rawlings school of divinity questionnaireWebMay 18, 2024 · The high incidence of cisplatin-induced nephrotoxicity in elderly patients may be associated with renal hypoperfusion; increased comorbidities, such as chronic … rawlings school of divinity writing guideWebThe nephrotoxic effect of cisplatin is cumulative and dose dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI result in impaired renal tubular function and acute renal failure, chronic kidney disease, uremia, and hypertensive nephropathy. rawlings school of divinityWebJun 22, 2024 · Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers. Despite its known … rawlings schoolWebCisplatin remains a major antineoplastic drug for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after … simple green motorcycle cleaner