WebRECENT progress in the serological diagnosis of syphilis, and the introduction of new, specific tests for treponemal diseases, have stressed the frequency and importance of non-syphilitic reactions of the type usually known as the biological false positive phenomenon. Moreover, it has been shown that the significance of non-specific reactions is frequently … Biological false positives are common in autoimmune diseases, chronic liver disease, following acute febrile illness, or during pregnancy. Despite this nonspecificity, nontreponemal tests remain valuable in assessing active disease because they are semi-quantitative, with results reported as a titer … See more Most laboratories offer serologic detection of syphilis. Unfortunately, the assays and their interpretation are complex and often misunderstood by physicians and patients. Because no one … See more In the U.S., the Centers for Disease Control and Prevention (CDC) has two accepted algorithms: the traditional (or forward) and the reverse algorithm. The traditional algorithm calls for a nontreponemal … See more To determine the best algorithm, clinical laboratorians need to assess the technical capabilities of their laboratories, collaborate with infectious diseases colleagues, and review the populations they serve. … See more When we at the University of Pittsburgh Medical Center implemented a new multiplex test that allowed for simultaneous assaying of treponemal and nontreponemal … See more
Syphilis testing in blood donors: an update - PMC - National …
WebA significant percentage of persons who react positively to serological tests for syphilis (STS) do not have syphilis but are referred to as chronic biologic false-positive (BFP) … WebDec 17, 2024 · A person is considered positive for syphilis when the non-treponemal (RPR) and treponemal antibody tests (e.g., TP-PA, or enzyme immunoassay) are both … gracie hamlin byron ga
Biological false-positive Definition & Meaning - Merriam Webster
WebJul 17, 2024 · Biological false-positive CSF reagin test results may result from tuberculosis or pyogenic or aseptic meningitis. However, even with sufficient treatment, … WebWhenever a screening test (RPR, VDRL) is positive, a more specific test (FTA-ABS, TP-MHA) should be used to confirm the test and rule out a "biologic false positive." A negative or "nonreactive" test may indicate: … WebReverse sequence testing can identify people previously treated for syphilis and those with untreated syphilis. False-positive results can occur in those with low likelihood of … chill spot cayman